KMID : 0882420100780020191
|
|
Korean Journal of Medicine 2010 Volume.78 No. 2 p.191 ~ p.197
|
|
The relationship between the ApoB/ApoA-I ratio and non-alcoholic fatty liver disease in prediabetic patients
|
|
Lee Ji-Ae
Jang Seung-Hun Min Jae-Hoon Kim Tae-Wan Jeong Woo-Shin Shim Choong-Nam Heo Woon-Je Jung Mi-Youn Lee Hyon-A Cho Yong-Kyun Hong Hyun-Pyo
|
|
Abstract
|
|
|
Background/Aims: The apolipoprotein B/A-I ratio (ApoB/A-I) is a powerful clinical indicator of atherosclerosis. Although numerous reports have shown the effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular disease, few reports have examined the relationship between NAFLD and the ApoB/A-I ratio. The aim of the study was to determine the association between NAFLD and the ApoB/A-I ratio in prediabetic patients.
Methods: This cross-sectional study was performed with data obtained from 701 patients (mean age, 47.9¡¾9.6 years) diagnosed with prediabetes. Serum lipid profiles including lipoprotein, apolipoprotein, and calculated ApoB/A-I ratio as well as metabolic syndrome parameters such as fasting glucose and insulin were measured in each subject.
Results: Among the 701 patients, 340 (48%) had NAFLD. The number of male patients was 490 (NAFLD+, 276; and NAFLD-,214). The odds ratios for the prevalence of NAFLD increased according to the quartiles of the ApoB/A-I ratio (1.886, 2.245, and 2.587) (p<0.001).
Conclusions: The prevalence of NAFLD correlated with high ApoB/A-I ratio, suggesting that NAFLD increases the risk for atherosclerosis progression in male prediabetic patients.
|
|
KEYWORD
|
|
NAFLD, Apolipoprotein B, Apolipoprotein A-I, Prediabetes, Atherosclerosis
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|